Mat 22:5 But they made light of [it], and went their ways, one to his farm, another to his merchandise:

In this verse, the focus is on the emotional reaction of those invited to the king's son's wedding and what they considered more important, their business interests. Symbolically, this is putting the mental realm of business above the emotional realm of relationships. The word translated as "make light" means specifically about neglecting or rejecting relationships.

"Make light of [it]" is from ameleô, which means "to have no care for," "to be neglectful of," and "to be careless." In its passive form, it means "to be slighted," and "to be overlooked."